In Silico Toxicological Assessment and Efficacy of Activated Carbon Derived from Low-Quality Face Tissues for Eosin Dye Adsorption

Abstract

Eosin dye is an efficient qualitative and quantitative chemical through various scientific and biological uses but it was demonstrated as a lethal substance to animal or human lung, liver, eye, kidney, Central Nerve System (CNS) and parts of gastrointestinal system. In many published studies, it removed via clay/carbon composite, lemon peel, or fly ash adsorption beside oxidation, filtration, photocatalysis, ion exchange, sonochemistry, nanotechnology, and others. Here, is another attempt to prepare an activated carbon from carbon-based material (low quality face tissue) where its capacity was determined by toxic anionic dye (Eosin B) – spectroscopic investigation. In this attempt, Eosin B showed an excellent removal and adsorption capacity starting from first 5 mL eluted from this prepared adsorbent. Removal of Eosin is important to human and environment where present In Silico study confirmed that Eosin B was safe to embryo or foetus health (during pregnancy), Cardio- topic including: Arrhythmia, Cardiac Failure, Heart Block, hERG Toxicity, Hypertension, and Myocardial Infarction, toxic to avian with high Rat Acute Toxicity (LD₅₀) lowest probability of lung, prostate, and renal cell lines even with its water solubility in aqua environment, Yes response towards P-glycoprotein substrate or multidrug resistance (MDR1) function in cancer pharmacotherapy. Also, Eosin B had BBB or CNS permeability as well as fish (Minnow) toxicity. It is safe for Renal OCT2 substrate, besides hERG I & II inhibitors, Hepatotoxicity, and skin sensitization, Cytochromes P450 under testing. Therefore, Eosin B is structurally toxic to human and environment in short – or long – term period.